GENETIC ENGINEERING & BIOTECHNOLOGY NEWS - “Identities of different cells rely heavily on the genome sites that are more open because only genes located in those regions can potentially become expressed and turned into proteins,” said Sihem Cheloufi, PhD, assistant professor in biochemistry at the University of California at Riverside.
Cheloufi added that to maintain cell identity during cell division, the locations of open and closed chromatin, or “chromatin organization,” must be faithfully passed onto the new replica of the genome, a task largely entrusted to CAF-1.